Methylchloroisothiazolinone, also referred to as MCI, is a preservative with antibacterial and antifungal effects within the group of isothiazolinones. It is effective against gram-positive and gram-negative bacteria, yeast, and fungi.
Methylchloroisothiazolinone is found in many water-based personal care products and cosmetics. Methylchloroisothiazolinone was first used in cosmetics in the 1970s. It is also used in glue production, detergents, paints, fuels, and other industrial processes. Methylchloroisothiazolinone is known by the registered tradename Kathon CG when used in combination with methylisothiazolinone.
Methylchloroisothiazolinone may be used in combination with other preservatives including ethylparaben, benzalkonium chloride, and bronopol.
Video Methylchloroisothiazolinone
Safety
In pure form or in high concentrations, methylchloroisothiazolinone is a skin and membrane irritant and causes chemical burns. In the United States, accepted concentrations are 15 ppm in rinse-offs and 8 ppm in other cosmetics. In Canada, the accepted concentrations are 15 ppm and 7.5 ppm respectively. The Canadian levels are also reflected in a paper published in the International Journal of Toxicology.
As of 2008, the International Agency for Research on Cancer (IARC), did not list methylchloroisothiazolinone as a known, probable, or possible human carcinogen, nor have in vivo tests found evidence of carcinogenic activity.
Allergic contact dermatitis
Methylchloroisothiazolinone can cause allergic reactions in some people. Since 2013, the use of this ingredient in cosmetics has received increased media coverage in the UK. Some cosmetics methylchloroisothiazolinone in have been investigated by the BBC programme Watchdog. The first publication of the preservative as a contact allergen was in 1988. Cases of photoaggravated allergic contact dermatitis, i.e. worsening of skin lesions after sun exposure, have also been reported.
Maps Methylchloroisothiazolinone
References
External links
- Record in the Household Products Database of NLM
- Methylchloroisothiazolinone at the National Library of Medicine
Source of article : Wikipedia
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